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What is the peritoneum? (In simple terms)

The peritoneum is a thin layer of tissue that lines the inside of the abdomen and covers most of the abdominal organs, including the stomach, intestines, and liver. Think of it as an internal protective lining of the abdomen. When cancer spreads to this lining, it is known as peritoneal carcinomatosis or peritoneal surface malignancy. While serious, specialised treatment can significantly extend life and improve quality of life.

What are peritoneal surface malignancies?

These are cancers that occur within the peritoneal cavity, the space between the abdominal organs and the abdominal lining. They may

Types of peritoneal tumours

Primary tumours (starting in the peritoneum)
Cancers that may spread to the peritoneal lining

What symptoms should you look out for?

Peritoneal surface tumours may not cause noticeable symptoms in the early stages. However, signs to watch for include

Advanced treatments at KD Cancer Centre

CRS — Cytoreductive surgery

This is a complex surgical procedure performed to remove all visible tumour deposits from the abdominal cavity. The procedure is performed by experienced surgical oncologists in specialised centres. The aim is to remove as much visible disease as possible.

HIPEC — Hyperthermic intraperitoneal chemotherapy

HIPEC is given immediately after CRS while the patient remains in the operating theatre. A warm, concentrated chemotherapy solution is circulated through the abdominal cavity for 60–90 minutes.

Benefits include

What to expect: your CRS + HIPEC journey

Understanding the process can reduce anxiety and help you prepare.

Step 1

Evaluation: CT scan, PET scan, and clinical assessment to determine suitability

Step 2

Preoperative preparation: Bowel preparation, nutritional optimisation, and anaesthetic review

Step 3

Surgery (CRS): Removal of visible tumour deposits (4–10 hours depending on extent)

Step 4

HIPEC: Heated chemotherapy circulated in the abdomen for 60–90 minutes under anaesthesia

Step 5

ICU and recovery: Usually 1–3 days in ICU, followed by 7–10 days in the ward

Step 6

Recovery at home: 4–6 weeks of gradual recovery with follow-up appointments

This is a major procedure available only at specialised centres. KD Cancer Centre is among the few centres in Gujarat to offer CRS + HIPEC with a dedicated multidisciplinary team.

PIPAC — Pressurised intraperitoneal aerosol chemotherapy

PIPAC delivers aerosolised (mist-form) chemotherapy directly into the abdominal cavity during keyhole (laparoscopic) surgery. The chemotherapy is sprayed under pressure, allowing deeper penetration at lower doses, which may reduce side effects.

Key features of PIPAC
  • Minimally invasive: Performed through small incisions
  • Targeted: Delivers chemotherapy directly to the cancer
  • Lower toxicity: Lower doses with minimal absorption into the bloodstream
  • Repeatable: Can be safely repeated every 6–8 weeks
PIPAC may be suitable for
  • Patients with inoperable or recurrent peritoneal disease
  • Those unable to tolerate high-dose systemic chemotherapy
  • Patients not suitable for CRS or HIPEC

Not everyone is a candidate for CRS + HIPEC.

These are highly specialised procedures and may not be suitable for all patients with peritoneal disease. The extent of disease (measured by the Peritoneal Cancer Index (PCI)), the type of primary cancer, and the patient’s overall fitness are carefully assessed before recommending treatment.

Our team will explain all options honestly, including whether other approaches such as PIPAC or systemic chemotherapy may be more appropriate.

FAQS

Is peritoneal surface malignancy curable?

Some patients may achieve long-term control or remission with specialised treatment. Outcomes depend on the type of cancer, extent of spread, and overall health.

What is the difference between CRS and HIPEC?

CRS is a surgery to remove visible tumours. HIPEC is heated chemotherapy given immediately afterwards to destroy microscopic cancer cells.

How long does recovery take after CRS + HIPEC?

Most patients need several weeks for recovery. Hospital stay is usually 1–2 weeks, followed by gradual improvement at home over 4–6 weeks.

Is HIPEC painful?

HIPEC is given while the patient is under anaesthesia during surgery, so no pain is felt during the procedure.

Who is suitable for PIPAC?

PIPAC may be considered for patients with recurrent, advanced, or inoperable peritoneal disease who are not suitable for major surgery.

Can these treatments improve quality of life?

Yes. In suitable patients, these treatments may reduce symptoms, slow disease progression, and improve quality of life.

Is CRS + HIPEC available in Gujarat?

Yes. KD Cancer Centre is among the specialised centres in Gujarat offering CRS + HIPEC with an experienced team.

When should I seek medical advice?

If you have persistent abdominal pain, bloating, unexplained weight loss, or altered bowel habits, consult a specialist promptly.